The Central Nervous System
Fibromyalgia is currently identified as a neurosensory disorder characterized by disturbances in the way the central nervous system interprets and evaluates stimuli (Gracely, 2002).
Fibromyalgia pain is thought to come more from the brain and spinal cord than from other areas of the body. There is a change in how the brain processes pain and other sensory information.
Pain pathways throughout the body are amplified in Fibromyalgia patients, pain can occur anywhere, and sensory hyper-responsiveness is common.
Treatments with opioids or other narcotic analgesics usually are NOT effective because they do not reduce the activity of neurotransmitters in the brain.
"These drugs have Never been shown to be effective in Fibromyalgia patients, and there is evidence that opioids might even worsen Fibromyalgia and other centralized pain states."